Showing posts with label anti-ageing. Show all posts
Showing posts with label anti-ageing. Show all posts

Thursday, 27 August 2015

THE SUNSHINE VITAMIN

Dear Readers,

It has been a slow day today. The weather's a tad bit gloomy and endless cups of coffee have been at my disposal since morning.

I had just reviewed some blood results for patients due for bio-identical hormones. It is our standard preliminary assessment whereby the whole range of hormones are evaluated. Much rightly so, since all the hormones are connected in uncountable ways.

What I have discovered amidst sheets and sheets of test reports, is that almost everyone appears to be deficient in vitamin D. This has come as a bit of an eye opener to me, 9 out of 10 people seem to be lacking in this suave hormone cum mineral entity. There is no statistical evidence to that data, just an observation on my side. Men and women alike, differing age groups and ethnicity - all share the patriotic similarity of being short of vitamin D. Talk about unity at a micronutrient level.

This has prompted me (in addition, to all the caffeine that has gone in), to write an article on Vitamin D and its " playing hard to get" status quo. Especially, when it has been offered to us in its abundance: sunlight.
I think its fair, to have just assumed all of us get plenty of this sunny vitamin.

Apparently not.

So lets just briefly discuss the attributes of this molecule:

Vitamin D is a fat-soluble vitamin that is naturally present in very few foods.  It is also produced endogenously when ultraviolet rays from sunlight strike the skin and trigger vitamin D synthesis. Vitamin D obtained from sun exposure, food, and supplements is biologically inert and needs to be activated by the liver & kidneys.

Vitamin D promotes calcium absorption in the gut and maintains adequate serum calcium and phosphate concentrations. This is highly important for bone health and remodelling.

Vitamin D has other roles in the body, including modulation of cell growth, neuromuscular and immune function, and reduction of inflammation. Many genes encoding proteins that regulate cell proliferation, differentiation, and apoptosis are modulated in part by vitamin D.




Causes of Vitamin D deficiency:

  • Nutritional deficiency - inadequate intake. Vitamin D-deficient diets are associated with milk allergy, lactose intolerance, ovo-vegetarianism, and veganism.
  • Limited exposure to sunlight
  • People with dark skin - increased skin melanin reduces Vitamin D synthesis.
  • Elderly people - reduced rate of synthesis
  • Prolonged breast feeding of infants
  • Inflammatory bowel disease or poor gut health - leads reduced absorption of vitamin D.
  • Compromised renal function
  • Obesity - greater amounts of subcutaneous fat sequester more of the vitamin and alter its release into the circulation
  • Excessive sunscreen
  • Northern latitudes
  • Air Pollution
  • Anti-Epileptic or HIV medications


 
So please don't underestimate the grand role of this vitamin.

Get your dose of sunlight from 10am to 3pm, about 15-20 minutes daily - a little longer if you are darker skinned.

Eat foods that can increase your levels naturally like: salmon, cod fish, eggs, fortified milk & cereals, cheese, mushrooms, apricot, squash, broccoli, liver and others.

Supplements both oral and sublingual are available for those with severe deficiencies. However, I strongly recommend a doctors consult prior to starting these.

Keep your gut healthy with balanced foods, adequate fibre and probiotics. A well oiled gut will aid in vitamin D absorption.

Drink plenty of fluids to prevent dysfunction of the kidneys.

Maintain a healthy weight so that there is no sequestration of vitamin D in the excess visceral fats.

Perform regular blood checks to ensure all hormones are functioning at their optimum.




Vitamin D Rocks!!



Dr. Aarthi Maria









Wednesday, 17 December 2014

Stem Cells


Dear Readers,

Today let's take the opportunity to discuss the very elusive and less understood topic amongst many - stem cells. An overview of their origin, behaviour and most importantly functions. 

Just imagine the stem cell as the mother of all cells - the one who nurtures and teaches the other cells, transforming them into adult cells with specific roles and responsibilities within the human body. Like in all hierarchy, there is one that also exists in this stem cell world. Some stem cells have greater capacity to differentiate and direct tissue systems, where as other stem cells may only have limited power and life span. It makes sense that stem cells would be more effective when obtained from an actively growing life source, whereby their degree of differentiation and maturity would be unrivalled. 


They serve as an internal repair system, dividing essentially without limit to replenish other cells as long as the person or animal is still alive. When a stem cell divides, each new cell has the potential either to remain a stem cell or become another type of cell with a more specialized function, such as a muscle cell, a red blood cell, or a brain cell. Stem cells are capable of replication, proliferation, differentiation and long term cell renewal.

Broadly stem cells are categorised as Embryonic and Non Embryonic (adult). Embryonic stem cells are derived from the embryo, as the name implies. These cells are very versatile and can differentiate into any cell type. Adult stem cells on the other hand, are not from the embryo, but instead from specific tissue systems like blood, muscle, skin etc. They can only differentiate into their own lineage and kind. The word "potency" describes the degree of differentiation capable of a stem cell.



The extensive research on stem cells and its capacity to replenish itself has brought about a profound eye opening in the medical world. Most research is on adult stem cells, as studying human embryonic cells is deemed unethical - and rightfully so too.



Just to add on, a popular subtype of adult stem cells are Mesenchymal Stem Cells. Mesenchymal stem cells (MSCs) are adult stem cells traditionally found in the bone marrow. They can also be isolated from other tissues including cord blood, peripheral blood, fallopian tube, and fetal liver and lung. Multipotent stem cells, MSCs differentiate to form adipocytes, cartilage, bone, tendons, muscle, and skin. Mesenchymal stem cells are a distinct entity to the mesenchyme, embryonic connective tissue which is derived from the mesoderm and differentiates to form hematopoietic stem cells.

So in conclusion, we have this great repair system whose consumables consist of our very own blood, fat and skin. Really makes life a whole lot easier when one needs a new kidney.

In actual fact however, stem cell research has pioneered numerous success stories. Stem cells are being used to treat a variety of disorders like Parkinsons, myocardial ischaemia, congenital disorders and many more. In years to come, we should be able to regenerate faulty organs within the body and restore balance and homeostasis.


Friday, 12 December 2014

The Miracle Hormone - Melatonin


Dear Friends & Readers,

Today, let's talk about the king of the hormones - melatonin. I am assuming that many of you may not have heard about this silent giant, who works stealthily at night.

Melatonin is a natural hormone primarily made by the pea sized pineal gland located in the mid-brain. It is also produced in the gut and retina. During the day the pineal is inactive. When the sun goes down and darkness occurs, the pineal is "turned on"  and begins to actively produce melatonin, which is released into the blood. Usually, this occurs around 9 pm. As a result, melatonin levels in the blood rise sharply and you begin to feel less alert. Sleep becomes more inviting. Melatonin levels in the blood stay elevated for about 12 hours - all through the night - before the light of a new day when they fall back to low daytime levels by about 9 am. Daytime levels of melatonin are barely detectable. 

Just a nutshell about sleep itself. Definitely an interesting physiology in my opinion. Still baffles me as to how God figures out things to such intricate of details. 

Sleep starts of with non-REM (rapid eye movement) phase - during this phase the body repairs and regrows tissues, builds bone and muscle, and strengthens the immune system. REM sleep happens 90 minutes after you fall asleep. The first period of REM typically lasts 10 minutes. Each of your later REM stages gets longer, and the final one may last up
to an hour. Your heart rate and breathing quickens. You can have intense dreams during REM sleep, since your brain is more active.

So where does melatonin  fit in in all this? Basically this wonder hormone keep the sleep wake & light cycle in check. If not for melatonin, humans may be running about like bunnies on Redbull, not being able to cease the body's activities. This in turn would result in defective healing and restoration of cells and organs. Simply put, we would be ageing at the speed of lightning.

People with sleep disorders generally have irregular melatonin levels. Melatonin release is inhibited by light - whether it is sunlight or even the blue light from your iPhone. So imagine the chaos in a shift workers hormone cascade. Take for a example, a nurse on night duty at the hospital - she is busy taking care of her patients and serving drugs - her pineal gland is going to be confused as to whether it should release melatonin or not. The last thing we want is a nurse doing CPR going into non-REM sleep!! Similarly, the same chaos occurs on long distance flights - the result jet lag. Besides being affected by occupational reasons, immuno-suppressed individuals may also be combating irregular melatonin levels due to compromised nutrition and depleted hormones. On the contrary, your friend whose always yawning at work is probably producing too much melatonin in the daytime - causing him to feel sleepy and less alert.
                                     

 Melatonin also functions as a potent antioxidant in our bodies. Amongst its numerous functions are:

a) free radical scavenger
b) stimulates anti-oxidative enzymes
c) lowers free radical generation
d) augments efficiency of other antioxidants
e) Protects against molecular damage

Melatonin and its metabolites are potent antioxidants with anti-inflammatory, hypotensive, cell communication enhancing, cancer fighting, brown fat-activating, and blood-lipid-lowering effects, thereby protecting tissues from a variety of insults. Melatonin has been shown to support circadian rhythm, hormone balance, reproductive health, cognition, mood, blood sugar regulation, and bone metabolism, while improving overall antioxidant status and lowering blood pressure. Melatonin may assist in preventing diabetic complications, and improving treatment outcomes in patients with cardiovascular disease and certain types of cancer.

For those of you against taking supplements, here's a list of melatonin boosting foods - pineapples, papaya, oranges, sweet corn, oats, rice, barley, bananas & tomatoes.

Now for those who are supplement addicts, please add this miracle hormone into your routine. Melatonin can be taken as a pill or sublingually. It has a short half and only stays active in the system for about 20 minutes. Ideally it is taken about 30 - 60 minutes before sleep. Do not be exposed to bright lights and activity before taking melatonin, as this would negate the effects of the supplement. Please also be warned that melatonin interacts with other drugs like oral contraceptive pills and anti-epileptics - so do consult your doctor before starting your melatonin journey!!

     


 If you think you might benefit from melatonin, click here


  • Pineapples
  • Bananas
  • Oranges
  • Oats
  • Sweet corn
  • Rice
  • Tomatoes
  • Barley
  • - See more at: http://naturalsociety.com/8-foods-naturally-increase-melatonin-sleep/#sthash.doWmO8T0.dpuf

    Overview of Some Melatonin-Boosting Foods:

    • Pineapples
    • Bananas
    • Oranges
    • Oats
    • Sweet corn
    • Rice
    • Tomatoes
    • Barley
    - See more at: http://naturalsociety.com/8-foods-naturally-increase-melatonin-sleep/#sthash.doWmO8T0.dpuf

    Overview of Some Melatonin-Boosting Foods:

    • Pineapples
    • Bananas
    • Oranges
    • Oats
    • Sweet corn
    • Rice
    • Tomatoes
    • Barley
    - See more at: http://naturalsociety.com/8-foods-naturally-increase-melatonin-sleep/#sthash.doWmO8T0.dpuf